. Polymerisation is achieved by a reaction with phosgene, conducted under biphasic conditions; the hydrochloric acid is scavenged with aqueous base. Before sharing sensitive information, make sure youre on a federal government site. It can also be used in the formation of solid polymeric electrolyte for potential application in electrochemical devices. Background. It is not a plasticizer,[11] although it is often wrongly labelled as such. [98] Despite its short half-life and non-bioaccumulating character, the continuous release of BPA into the environment causes continuous exposure to both plant[104] and animal life. BPA is an important industrial chemical, which is mainly used as a raw material of polycarbonate and epoxy resin. Structural formula Name CAS Reactants; Bisphenol AF: 1478-61-1: Phenol: Hexafluoroacetone: Bisphenol F: 620-92-8: Phenol: The subchronic study was designed to characterize potential effects of BPA in a wide range of endpoints, including prostate and mammary glands, metabolic changes, and cardiovascular endpoints. [43][44] This is achieved by a reaction with epichlorohydrin under basic conditions. [22][17][72], The health effects of BPA have been the subject of prolonged public and scientific debate,[12][13][14] with PubMed listing more than 16,000 scientific papers as of 2022. The review was documented in four memoranda and their attachments: Strong consumer and scientific interest in the safety of BPA has prompted FDA to support additional studies to provide further information and address apparent inconsistencies in the scientific literature about BPA. Bisphenol A- (epichlorhydrin)epoxy resin, polymer with polyethylene glycol, castor oil and triethylenetetramine IUPAC names 1 Print infocard Substance identity Substance identity The 'Substance identity' section is calculated from substance identification information from all ECHA databases. FDA can make regulatory changes based on new safety or usage information. This compound is synthesized by the condensation of acetone with phenol. Liquid Epoxy Resins Show entries The next question is how do you make epoxy resin. Free of claims are used to indicate that a product does not contain a certain material, such as BPA, but they can sometimes be misleading. An amendment of the food additive regulations based on abandonment is not based on safety, but is based on the fact that the regulatory authorization is no longer necessary for the specific use of the food additive because that use has been permanently and completely abandoned. [89], BisphenolA's interacts with the estrogen-related receptor (ERR-). 1675-54-3 Chemical Name: BISPHENOL A DIGLYCIDYL ETHER RESIN CBNumber: CB3749115 Molecular Formula: C21H24O4 Molecular Weight: 340.41 MDL Number: MFCD00080480 MOL File: 1675-54-3.mol MSDS File: SDS Modify Date: 2022-12-30 16:20:48 Request For Quotation BISPHENOL A DIGLYCIDYL ETHER RESIN Properties SAFETY In order to formulate an epoxy adhesive, one must have either bisphenol A or bisphenol F. Bisphenol A (BPA) is generally preferred for its curing properties. Our line of powerful Liquid Epoxy Resins -including Bisphenol A, Modified Bisphenol A, Bisphenol A/F, Modified Bisphenol A/F, Bisphenol F offers the reliability, protection and performance you need, backed by the local customer support Only Olin can provide, virtually anywhere in the world. just looking for general information about environmental health research or the institute, this page will help. Specialty Chemicals And Polymers. Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats. The health effects of BPA have been the subject of prolonged public and scientific debate. 250/ Ton Get Latest Price. You may have heard claims that BPA exposure causes health effects in people. [22] The European Chemicals Agency has added BPA to the Candidate List of substances of very high concern (SVHC), which would make it easier to restrict or ban its use in future. Bisphenol A is the chemical product of combining one acetone unit with two phenol groups. FDA will also continue to consult with other expert agencies in the federal government, including the National Institutes of Health (and the National Toxicology Program), the Environmental Protection Agency, the Consumer Product Safety Commission, and the Centers for Disease Control and Prevention. Epub 2014 Feb 4. b) Delclos KB, Camacho L, Lewis SM, Vanlandingham MM, Latendresse JR, Olson GR, Davis KJ, Patton RE, Gamboa da Costa G, Woodling KA, Bryant MS, Chidambaram M, Trbojevich R, Juliar BE, Felton RP, Thorn BT. When dropping is completed within half an hour, heat it for 12-24 hours under temperature 70-80C Stop the heating after bisphenol A is completely disappeared validated by TLC method. When possible, opt for glass, porcelain or stainless steel containers, particularly for hot food or liquids. This is called a two-step method. Therefore, they are effective adhesion for most substrates such as glass, ceramics, silicon wafers, and polymer materials. The epoxide resins (also widely known as epoxy resins and, occasionally, as ethoxyline resins) are characterised by the possession of more than one 1,2-epoxy group (I) per molecule. CAS number(s): 55818-57- . Other Details: - Bisphenol resin is extensively used with consumer products such as applying coatings inside of food and beverage cans as this leave no bad effects or any risk of hazard to human health. BPA can be found in a range of products, such as: plastic food storage containers, including: pitchers. General description. Bisphenol A (BPA, 80-05-7) is an organic compound used predominantly in the production of products made of polycarbonate plastic and epoxy resins that line food and beverage cans. [28], The synthesis of BPA still follows Dianin's general method, with the fundamentals changing little in 130 years. FDA continues to review the available information and studies on BPA. Paper recycling can be a major source of release when this includes thermal paper,[9][97] leaching from PVC items may also be a significant source,[93] as can landfill leachate. Epoxy resins are made by reacting epichlorohydrin (ECH) and bisphenol A to produce a different chemical substance called bisphenol A diglycidyl ether (also known as BADGE or DGEBA). Toxicol Sci. Search for free and find new suppliers for chemical products, pharmaceuticals and APIs. Whether you're producing perfume or PVC plastics, the chances are intermediates will . The reaction is catalyzed by a strong acid, such as hydrochloric acid (HCl) or a sulfonated polystyrene resin. [27], In terms of the endocrine disruption controversy, the British biochemist Edward Charles Dodds tested BPA as an artificial estrogen in the early 1930s. TM 332 epoxy resin (Dow Chemical, Midland, TX, USA) with the epoxy group content of 24.6%-25.1% and epoxy equivalent of 171-175 which is referenced as DGEBA and with ERISYS Resorcinol . From durable sneakers to waterproof jackets, chemistry plays a big role in all types of outdoor activities. Toxicity evaluation of bisphenol a administered by gavage to sprague dawley rats from gestation day 6 through postnatal day 90. Bisphenol A (BPA) is an organic synthetic compound with the chemical formula (CH3)2C(C6H4OH)2 belonging to the group of diphenylmethane derivatives and bisphenols, with two hydroxyphenyl groups. Epoxy groups located at both ends of the molecule can undergo reactions of ring-opening, cross-linking and solidity with amines, anhydrides, and other curing agents of epoxy resins. Brand Names: Not applicable . 2011 Nov;124(1):149-60. k) He Z, Paule MG, Ferguson SA. NIEHS has a goal to ensure job opportunities and career enhancements programs for both our work force and our community. 12 oz. Surface chemistry the study of chemical . fatty acid dimers, +undefined-86-13650506873 +undefined-86-13650506873. Table 1, Table 2 present the . Toxicol Lett. Some of these studies have raised questions about the safety of ingesting the low levels of BPA that can migrate into food from food contact materials. BPA is a starting material for the synthesis of plastics, primarily certain polycarbonates and epoxy resins, as well as some polysulfones and . BPA is regularly used to strengthen products for human health and safety. Epoxy resins made with BPA are tough and readily adhere to metal surfaces, making them excellent materials for protective coatings. EC number: 500-130-2 The study included an in utero phase, direct dosing to pups to mimic bottle feeding in neonates, and employed a dose range covering the low doses where effects have been previously reported in some animal studies, as well as higher doses where estrogenic effects have been measured in guideline oral studies. Recently completed a rodent subchronic study [7] intended to provide information that would help in designing a long-term study that is now underway (see below). At 830C). The epoxide functional group is also collectively called epoxy. The CLARITY Study, a 5+ year, multipronged U.S. federal government research program and the largest study ever done on BPA, confirms BPAs safety. BPA is an industrial chemical used to make a hard, clear plastic known as polycarbonate. BPA seems to bind strongly to ERR- (dissociation constant = 5.5 nM), but only weakly to the ER. [2][7] BPA is produced on an industrial scale by the condensation of phenol and acetone, and has a global production scale which is expected to reach 10 million tonnes in 2022.[8]. Health concerns have also been raised about these substitutes. Physical State: Powder. Make any industrial chemical reactions run smoothly with the organic intermediate compounds available at Alibaba.com's chemical store. Scientific studies show that in humans BPA is quickly metabolized and eliminated from the body. BPA is a structural component in polycarbonate beverage bottles. These meetings are listed in the NIEHS Events Calendar and are open to the general public. (2013) A new approach to synergize academic and guideline-compliant research: the CLARITY-BPA research program. Epoxy resin, on the other hand, has been of substantial significance to engineering for many decades. [2]FDA Science Board Subcommittee on Bisphenol A. To fix the amount of fixed bisphenol A and make excess epichlorohydrin can obtain DGEBA. Epoxy resin is a polymer with the molecular formula (C11H12O3)n, which is a general term for a class of polymers containing more than two epoxy groups in the molecule. Cured epoxy resins are inert materials used as protective liners in metal cans to maintain the quality of canned foods and beverages, and have achieved wide acceptance for use as protective coatings because of their exceptional combination of toughness, adhesion, formability, and chemical resistance. Reprod Toxicol. Polycarbonate plastic used in automobiles helps make cars lighter and more fuel-efficient while maintaining safety. It is prepared by the reaction of two equivalents of phenol with one equivalent of acetone. Empirical Formula (Hill Notation): C21H24O4 CAS Number: 1675-54-3 Molecular Weight: 340.41 Beilstein: 299026 EC Number: 216-823-5 MDL number: MFCD00080480 PubChem Substance ID: 57654090 NACRES: NA.77 Pricing and availability is not currently available. [91], BPA has been detectable in the natural environment since the 1990s and is now widely distributed. The site is secure. Products like bike helmets, police shields, reading glasses and bullet-proof glass are all shatter resistant because of BPA. NIEHS is committed to conducting the most rigorous research in environmental health sciences, and to communicating the results of this research to the public. [11]. The molecular structure of bisphenol A epoxy resin contains aromatic rings and lateral hydroxyl groups, which is beneficial to improve adhesion; in addition, the aromatic ring structure also gives the resin higher rigidity, tensile strength and thermal stability; in general, The main characteristics of bisphenol A epoxy type include: fast light curing reaction rate, high hardness and tensile strength after curing, high gloss of the film layer, and excellent chemical corrosion resistance. When the number-average molecular weight is less than 400, the main component is bisphenol A diglycidyl ether (DGEBA, relative molecular weight 340). [92] It is primarily a river pollutant,[93] but has also been observed in the marine environment,[94] in soils,[95] and lower levels can also be detected in air. NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. Comparatively minor amounts of BPA are also used as additives or modifiers in some commodity plastics. The ACC mark, Responsible Care, the hands logo mark, CHEMTREC, TRANSCAER, and americanchemistry.com are registered service marks of the American Chemistry Council, Inc. May also be known as: Polycarbonate, Epoxy Resins. One reason people may be concerned about BPA is because human exposure to BPA is widespread. More than 140,000 products, 270,000 supply sources and 4,400 company addresses. Another reason for concern, especially for parents, may be because some animal studies report effects in fetuses and newborns exposed to BPA. Published September 2022. Polycarbonate plastic is a lightweight, high-performance plastic that possesses a unique balance of toughness, optical clarity, high heat resistance, and excellent electrical resistance. . [105] As such, the precise effects of BPA on the growth, reproduction, and development of aquatic organism is not fully understood. In recent years, many claims have been made about the health effects of BPA. The method is a modification of NIOSH P&CAM It is important to note that scientific experts at FDA, and other regulatory bodies, review the full weight of the scientific evidence when making decisions about safety. [11] www.who.int/foodsafety/areas_work/chemical-risks/bisphenol/en/, An official website of the United States government, : Heightened interest in the safe use of BPA in food packaging has resulted in increased public awareness as well as scientific interest. Polycarbonate plastic is used to make critical components of many medical devices and their housings. Government regulators have the responsibility of reviewing all studies and considering issues like study design and quality and whether the result of any particular study was repeated in other studies. Toxicol Appl Pharmacol. Thanks to their high strength, versatility, and excellent adhesion to a variety of surfaces, epoxy resins have gained wide acceptance in diverse applications (coatings, electrical, casting resins, composites, etc.). Its optical clarity allows direct observation of blood or other fluids to monitor proper flow. [37] Crystals form in the monoclinic space group P 21/n (where n indicates the glide plane); within this individual molecules of BPA are arraigned with a 91.5 torsion angle between the phenol rings. [42] This process converts the individual molecules of BPA into large polymer chains, effectively trapping them. FDAs current perspective, based on its most recent safety assessment, is that BPA is safe at the current levels occurring in foods. The FDA review has not found any information in the evaluated studies to prompt a revision of FDAs safety assessment of BPA in food packaging at this time. On the regulatory front, FDAs regulations authorize FDA to amend its food additive regulations to reflect when certain uses of an additive have been abandoned. The results, released in 2018 by the U.S. National Toxicology Program, were accompanied by a statement from Dr. Stephen Ostroff, Deputy Commissioner for Foods and Veterinary Medicine at the U. S. Food and Drug Administration (FDA), saying: our initial review supports our determination that currently authorized uses of BPA continue to be safe for consumers.. [1] This draft assessment was reviewed by a Subcommittee of FDAs Science Board, which released its report at the end of October 2008. At high concentrations, BPA also binds to and acts as an antagonist of the androgen receptor (AR). 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